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American College of Veterinary Pathologists
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Abstract Detail

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Section: Natural Disease
Keyword: Urinary System

Poster Number: Poster N-4

RETROSPECTIVE EVALUATION OF RENAL BIOPSIES FOR EVIDENCE OF IMMUNE-COMPLEX MEDIATED GLOMERULAR DISEASE IN DOGS

S.M. Schneider1, M. Nabity1, R.E. Cianciolo, G.E. Lees3,1Department of Veterinary Pathobiology, TexasA&M University, College Stations, TX; 2Department of Pathology and Laboratory Medicine, University ofNorth Carolina, Chapel Hill, NC; 3Department of Veterinary Small Animal Clinical Sciences, TexasA&M University, College Station, TX

A retrospective evaluation of all cases submitted toTexas Veterinary Renal Pathology Service (TVRPS) between January 2007 andMarch 2012 was performed to determine the proportion of dogs presented forclinical signs of glomerular disease that have immune-complex mediatedglomerulonephritides (ICGN) and assess the utility of ultrastructuralanalysis in the evaluation of renal biopsy specimens.  Casesincluded in the study were those of  dogs from North America without aprevious diagnosis by renal biopsy, evaluated for a clinical suspicion ofprimary glomerular disease; 435 (72%) of 605 submitted cases wereincluded.  Cases were evaluated by light microscopy, immunofluorescence(IF) and electron microscopy (EM).  Of 435 cases, 46% (200) hadICGN; 16.8% (73) had glomerulosclerosis, 13.6% (59) had amyloidosis, 6.9%(30) had glomerular lesions without immune complexes (IC), 5% (22) hadglomerular and tubulointerstitial lesions without IC, 3.2% (14) hadnon-amyloidotic fibrillary glomerulopathy, 3.2% (14) had primarytubulointerstitial disease, 1% (5) had other findings, and 4.1% (18) werenon-diagnostic.  Of the confirmed ICGN cases 25% (49/200) required EMfor definitive diagnosis.  Furthermore, in 3.5% (7/200) of cases EMrevealed IC deposition when ICGN was not suspected during preliminaryhistologic examination.  Additionally, 1.8% (8/435) of all casesdiagnosed as ICGN on light microscopy did not have IC via EM. In conclusion, a substantial portion of dogs biopsied for suspectedglomerular disease have conditions other than amyloid or ICGN, necessitatingrenal biopsy for accurate diagnosis.  Furthermore, EM is often requiredto diagnose immune-complex mediated disease.

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