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ACVP 2008 Annual Meeting

PRE-MEETING AND POST-MEETING WORKSHOPS

Register for your choice of Pre- and Post-Meeting Workshops on the registration form. Each workshop is available for an additional fee. All Pre-Meeting Workshops are held on Saturday, November 15 and run concurrently. All Post-Meeting Workshops are held on Wednesday afternoon, November 19 and run concurrently.

PRE-MEETING WORKSHOPS

Saturday, November 15, 2008

8:00 a.m.-5:00 p.m.
Registration Fee: $275
ASVCP Pre-Meeting Workshop
Biomarkers in Preclinical Studies: A Reality Check
Session Co-Chairs: Laura I. Boone, DVM, PhD*
Research Advisor, Pathology, Eli Lilly and Company, Greenfield, IN

Daniela Ennulat, DVM, PhD*
Director of Clinical Pathology, GlaxoSmithKline, King of Prussia, PA

8:00 a.m.-9:00 a.m.
Qualification of Biomarkers
Laura I. Boone, DVM, PhD*

9:00 a.m.-10:00 a.m.
Biological Considerations in the Application of Biomarkers in Preclinical Studies
Daniela Ennulat, DVM, PhD*

10:00 a.m.-10:30 a.m.
Refreshment Break

10:30 a.m.-11:30 a.m.
Cardiac Biomarkers
Philip F. Solter, DVM, PhD*
Associate Professor, Department of Pathobiology, University of Illinois, Urbana-Champaign, Urbana, IL

11:30 a.m.-12:30 p.m.
Lunch (on your own)

12:30 p.m.-1:30 p.m.
Bone Biomarkers in Preclinical Research: A Ten Year Experience
Aurore Varela, DVM, MSc
Senior Research Scientist, Charles River Laboratories, Senneville, Quebec

1:30 p.m.-2:30 p.m.
Endocrine Biomarkers: Pulses, Surges & Circadian Rhythms
Ilene R. Cohen, PhD
Head, Investigative Toxicology, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, IN

2:30 p.m.-3:00 p.m.
Refreshment Break

3:00 p.m.-4:00 p.m.
Renal Biomarkers
Daniela Ennulat, DVM, PhD*

4:30 p.m.-5:00 p.m.
Closing Remarks and Discussion

Saturday, November 15, 2008

8:00 a.m.-5:00 p.m.
Registration Fee: $175
C.L. Davis Foundation Pre-Meeting Workshop
Orthopedic Pathology - Fifty Years On: Revisiting 22 Classic Entities from the 1958 ACVP Meeting on Skeletal Disease
Session Chair: Bruce Williams, DVM*
Chair, AFIP Telemedicine, Armed Forces Institute of Pathology, Rockville, MD

In 1958, the American College of Veterinary Pathologists held a day-long-serminar on "Skeletal Diseases". Many of the legends of veterinary pathology participated in this conference, including T.C. Jones, Charles Davis, Peter Olafson, Peter Kennedy, Leon Saunders, and more. Fifty years later, in 2008, Dr. Steve Weisbrode and Dr. Roy Pool and a host of guest presenters will review these cases, using much of the original materials, to reveal what we have learned in the last 50 years on 22 classic entities. It's a look into the past and present that no one should miss. Attendees will receive a copy of the CD containing the transcript of the original meeting with original kodachromes, references, and biographies of the original presenters.

$175 provides attendees with 8 hours of RACE-accredited continuing education, refreshments, syllabus, and a DVD set with the transcript and 260 images from the 1958 symposium, biographies of the original presenters, and 23 virtual slides of the entities presented in 1958 and 2008.

8:00 a.m.-5:00 p.m.
Second Annual Coalition Scientific Conference
(by invitation)

Saturday, November 15, 2008

1:30 p.m.-5:00 p.m.
Registration Fee: $100
ITPIG Pre-Meeting Workshop
Advances in Fluorescent Microscopy and Imaging
Session Chair: Kevin A. Keane, DVM, PhD
Principal Research Pathologist, Schering-Plough, Lafayette, NJ

1:30 p.m-1:40 p.m.
Welcome and Introduction
Kevin A. Keane, DVM, PhD

1:40 p.m.-2:15 p.m.
Not Just a Pretty Picture: Multi-Disciplined Applications of Confocal Microscopy for Toxicological Investigations
Wendy Jo Freebern, PhD
Senior Research Investigator, Bristol-Myers Squibb Research and Development, East Syracuse, NY

2:15 p.m.-3:00 p.m.
Practical Image Analysis from a Pathologist’s Perspective
Frank A. Voelker, DVM, MS*
Pathology Experts LLC, Brewster, MA

3:00 p.m.-3:15 p.m.
Refreshment Break

3:15 p.m.-4:00 p.m.
Morphologic Endpoint Quantification in Veterinary Pathology: Quantitative Imaging Cytometry and Stereologic Approaches
Richard A. Peterson, II, DVM, PhD*
Director, Molecular and Ultrastructural Pathology, GlaxoSmithKline, Research Triangle Park, NC

4:00 p.m.-4:45 p.m.
Toxicity and Biomedical Imaging of Layered Nanohybrids in the Mouse
Alexander Yu Nikitin, MD, PhD
Associate Professor of Pathology, Department of Biomedical Sciences, Cornell University, Ithaca, NY

4:45 p.m.-5:00 p.m.
Questions and Discussion

7:00 p.m.-8:30 p.m.
Opening Reception and Focused Poster Session

*ACVP Diplomate

POST-MEETING WORKSHOPS

Registration Fees:

Member/Non-Member - $165
Resident/Fellow/Graduate Student - $100
Professional Student** - $50

**The number of student registrations available for the workshops is limited.

Wednesday, November 19, 2008

1:00 p.m.-5:00 p.m.
Post-Meeting Workshop I
Morphologic Evaluation of the Testis in Laboratory Animal Species
Session Chair: Wayne Dochterman, DVM*
Covance, Madison, WI
Session Co-Chair: Sabine Rehm, DrMedVet*
Consultant, Paoli, PA

1:00 p.m.-1:10 p.m.
Brief Review of STP Position Paper, Workshop Objectives, and Outline of the Agenda
Sabine Rehm, DrMedVet*

Brief review of STP position paper, workshop objective, and outline of the agenda.

1:10 p.m.-2:10 p.m.
Practical Stage-Aware Evaluation of the Testis by Pathologists
Justin D. Vidal, DVM, PhD*
Director, Pathology, GlaxoSmithKline, King of Prussia, PA

Practical Stage-dependent Evaluation of Testis by Pathologists.
This would include review of normal spermatogenesis, explain staging chart of the rat, provide weighted guidance on stage-dependent evaluation, show one example of test article induced stage-dependent finding, review species differences using charts for mice, dog, monkey and rabbit. Discuss the reporting of routine morphologic observations and how this impacts the reporting of stage-dependent evaluation findings. Include justification for and when stage-dependent evaluation needs to be done and correlation with results from fertility studies. Handout would contain detailed information i.e. fixation, processing.

2:10 p.m.-2:50 p.m.
Standardized Diagnostic Terminology for Testicular Lesions
George L. Foley, DVM, PhD*
Director of Pathology, Schering Plough, Summit, NJ

Standardized Diagnostic Terminology for Testicular Lesions.
Review STP position paper, will have an emphasis on nomenclature for stage-dependent lesions.

2:50 p.m.-3:10 p.m.
Refreshment Break

3:10 p.m.-4:00 p.m.
Confounding Issues of Immature and Peripubertal Testes
Dianne M. Creasy, PhD, FRC Path
Senior Director of Pathology, Huntingdon Life Sciences, East Millstone, NJ

Issues Related to Immature, Prepubertal or Pubertal Testis -- How to Recognize and What to Do?
Species differences in rat, dog, and monkey, terminology, reporting, guide on distinguishing Test Article-related effects, also include some other background lesions not addressed in introductory presentation by Sabine Rehm.

4:00 p.m.-4:30 p.m.
Potential Pitfalls Evaluating Rat Testis in Subacute Toxicity Studies
Sabine Rehm, DrMedVet*

Stage-dependent Effects in Rats Related to Reduced Body Weight Gain Spontaneous Background Lesions and Artifacts.
Findings are not uncommon in tox studies with reduced weight gain with increased dose. Discuss findings in seminal vesicles/prostate relative to reduced testosterone levels. Present stage-dependent background findings and other spontaneous lesions and artifacts not mentioned by other speakers.

4:30 p.m.-5:00 p.m.
Questions and Discussion

Wednesday, November 19, 2008

1:00 p.m.-5:30 p.m.
Post-Meeting Workshop II
A Contemporary Approach to Renal Biopsy Pathology in Veterinary Medicine
Session Chair: Brian R. Berridge, DVM, PhD*
Director, Regulatory and Discovery Pathology, GlaxoSmithKline Safety Assessment, Research Triangle Park, NC

Session Co-Chair: Cathy A. Brown, VMD, PhD*
Professor, Department of Pathology and Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA

1:00 p.m.-1:30 p.m.
Introduction to Current Concepts of Renal Biopsy Application in Clinical Veterinary Medicine
Shelly L. Vaden, DVM, PhD, Diplomate, ACVIM
Professor, Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC

1:30 p.m.-2:00 p.m.
Approach to Renal Biopsy Interpretation
Brian R. Berridge, DVM, PhD*

2:00 p.m.-2:30 p.m.
Pathology of Glomeruli in Primary and Secondary Glomerular Disease
Cathy A. Brown, VMD, PhD*

2:30 p.m.-3:00 p.m.
Pathology of Tubulointerstitial Disease
Brian R. Berridge, DVM, PhD*

3:00 p.m.-3:30 p.m.
Refreshment Break

3:30 p.m.-4:00 p.m.
Ultrastructure of Renal Disease
Fred J. Clubb, DVM, PhD*
Professor, Department of Veterinary Pathobiology, Texas A&M University, College Station, TX

4:00 p.m.-4:30 p.m.
Clinical Correlates of Renal Disease
George E. Lees, DVM, MS*
Professor, Small Animal Clinical Sciences, Texas A&M University, College Station, TX

4:30 p.m.-5:30 p.m.
Renal Biopsy Case Presentation: A Clinician-Pathologist Partnership
Brian R. Berridge, DVM, PhD*
Cathy A. Brown, VMD, PhD*
Fred J. Clubb, DVM, PhD
George E. Lees, DVM, MS
Shelly L. Vaden, DVM, PhD, Diplomate ACVIM

Wednesday, November 19, 2008

1:00 p.m.-5:00 p.m.
Post-Meeting Workshop III
Morphometrics and Analytical Applications in Digital Microscopy
Session Chair: Bruce Williams, DVM*
Chair, AFIP Telemedicine, Armed Forces Institute of Pathology, Rockville, MD

With recent advances in digital imaging and the advent of virtual slides, advanced imaging techniques and analytical algorhythms are becoming commonplace in all areas of diagnostic and toxicologic pathology. Automatic measurements of cells as well as non-cellular components in tissue, quantification of immunohistochemical staining, rare event detection, and color deconvolution in the analysis of differential staining are tools that are now available to the bench pathologist. This seminar will cover the basics of these technologies as well as highlight current applications by leading researchers in this area.

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