Sunday, November 11, 2007
Experimental Disease Specialty Group Session I
(Vet. Path. Abstracts 104-141)
1:30 p.m.-5:00 p.m.

Chair: M.R. Ackermann
Committee Members: K. Boyd (Co-Chair), B. Buetow, D. Gardner, C. Brayton, and L. Diehl

Platform Presentations

1:30 p.m.-1:45 p.m.
DELETION OF THE FOCAL ADHESION KINASE GENE IN MURINE MAMMARY EPITHELIUM. 
T. Nagy, H. Wei, T.-L. Shen, X. Peng , C.-C. Liang, B. Gan, and J.-L. Guan
Keyword: Mammary, Abstract Number 104

1:45 p.m.-2:00 p.m.
CREATION AND CHARACTERIZATION OF A DOXYCYCLINE-INDUCIBLE MOUSE MODEL OF THYROID-TARGETED RET/PTC1 ONCOGENE AND LUCIFERASE REPORTER GENE CO-EXPRESSION. 
K.A.B. Knostman, S.M. Jhiang, and C.C. Capen
Keyword: Endocrine System, Abstract Number 105

2:00 p.m.-2:15 p.m.
HISTOPATHOLOGY OF SUBACUTE TO CHRONIC CRYOABLATION AND HIGH INTENSITY ULTRASOUND (HIU) LESIONS CORRELATED TO CONTRAST-ENHANCED (CE) MR-IMAGES IN NORMAL DOG PROSTATES. 
D.M. Bouley, B. Daniel, K. Butts Pauly, C. Diederich, and G. Sommer
Keyword: Reproductive System, Abstract Number 106

2:15 p.m.-3:00 p.m.
Invited Speaker
CANINE TVT:  EVOLUTION OF SOMATIC TUMOUR CELL AS TRANSMISSIBLE PARASITES. 
C. Murgia

3:00 p.m.-3:30 p.m.
REFRESHMENT BREAK - VISIT THE POSTERS AND EXHIBITS!

3:30 p.m.-3:45 p.m.
ENTERIC MICROBIOTA PROMOTE CHEMICAL LIVER CARCINOGENESIS IN MICE. 
Y. Feng, E.J. Theve, J.L.A. Fiala, J.M. Essigmann, J.G. Fox, and A.B. Rogers
Keyword: Liver, Abstract Number 107

3:45 p.m.-4:00 p.m.
THE AK MOUSE MODEL OF PARKINSONS DISEASE. 
C. Zeiss, B. Singh, J. Wilson, Z. Guo, H.Vasavada, and H.Allore
Keyword: Nervous System, Abstract Number 108

4:00 p.m.-4:15 p.m.
EXPERIMENTAL MELAMINE AND CYANURIC ACID TOXICOSIS IN CATS. 
P.A. Pesavento, B. Puschner, R.H. Poppenga, and L.J. Lowenstine
Keyword: Urinary System, Abstract Number 109

4:15 p.m.-5:00 p.m.
Invited Speaker
TASMANIAN DEVIL TUMOR:  CHARACTERISTICS AND MOLECULAR CHARACTERIZATION.
S. Pyecroft

Tuesday, November 13, 2007
Experimental Disease Specialty Group Session II
 (Vet. Path. Abstracts 110-141)
1:30 p.m.-5:00 p.m.

Chair: M.R. Ackermann,
Committee Members: K. Boyd (Co-Chair), B. Buetow, D. Gardner, C. Brayton, and L. Diehl

Platform Presentations

1:30 p.m.-2:15 p.m.
Invited Speaker 
INTO THE MELTING POT:  THE MELDING OF PATHOLOGY, PHARMACOLOGY, AND MEDICAL IMPLANT DEVICES FOR OCCLUSIVE ARTERIAL DISEASE. 
L. Perkins

2:15 p.m.-2:30 p.m.
ADIPONECTIN GENE EXPRESSION AND PROTEIN SECRETION ARE UNAFFECTED IN A HIGH-FAT FED, OBESE DOG MODEL. 
B. Brunson, D. Bedi, E. Plaisance, and R. Judd
Keyword: Cardiovascular System, Abstract Number 110

2:30 p.m.-2:45 p.m.
MACROPHAGE ACTIVATION ASSOCIATED WITH DIASTOLIC DYSFUNCTION IN THE SIV/MACAQUE MODEL OF HIV CARDIAC DISEASE. 
K. Kelly, J. Karper, D. Bedja, S. Queen, K. Gabrielson, P. Tarwater, R. Adams, and J. Mankowski
Keyword: Cardiovascular System, Abstract Number 111

2:45 p.m.-3:00 p.m.
MORPHOLOGIC AND MORPHOMETRIC RELATIONSHIP OF BURN DEPTH, VASCULAR PATENCY AND CELL INJURY IN A PARTIAL THICKNESS BURN MODEL. 
D.K. Meyerholz, J.C. Sokolich, T.D. Light
Keyword: Cardiovascular System, Abstract Number 112

3:00 p.m.-3:30 p.m.
REFRESHMENT BREAK - VISIT THE POSTERS AND EXHIBITS!

3:30 p.m.-4:15 p.m.
Invited Speaker 
ATHEROSCLEROSIS –THE HEART OF THE MATTER. 
T. Clarkson

4:15 p.m.-4:30 p.m.
TNF ALPHA UP-REGULATES MUC5AC IN EQUINE AIRWAY EPITHELIAL CELLS. 
K. Oslund, D. Chen and R. Wu
Keyword: Respiratory System, Abstract Number 113

4:30 p.m.-4:45 p.m.
IDENTIFICATION OF CYNOMOLGUS MONKEYS (MACACA FASCICULARIS) THAT ARE HIGH AND LOW RESPONDERS TO TOLL-LIKE RECEPTOR 4 AGONISTS (TLR4). 
C.W. Frevert, M. Wurfel, S. Mongovin, K. Larsen, M.B. Agy, and T.R. Martin,
Keyword: Primate, Abstract Number 114

4:45 p.m.-5:00 p.m.
THE MAGNITUDE OF BLOOD DERIVED INTERFERON-GAMMA INDUCED BY MYCOBACTERIUM TUBERCULOSIS EARLY SECRETED ANTIGENIC TARGET-6 PREDICTS DISEASE OUTCOME IN MICE. 
G.L. Beamer, D.K. Flaherty, B. Vesosky, and J. Turner
Keyword: Infectious Disease, Abstract Number 115

Poster Presentations

E1*
DELETION OF THE FOCAL ADHESION KINASE GENE IN MURINE MAMMARY EPITHELIUM. 
T. Nagy, H. Wei, T.-L. Shen, X. Peng , C.-C. Liang, B. Gan, and J.-L. Guan
Keyword: Mammary, Abstract Number 104

E-2*
CREATION AND CHARACTERIZATION OF A DOXYCYCLINE-INDUCIBLE MOUSE MODEL OF THYROID-TARGETED RET/PTC1 ONCOGENE AND LUCIFERASE REPORTER GENE CO-EXPRESSION.  K.A.B. Knostman, S.M. Jhiang, and C.C. Capen
Keyword: Endocrine System, Abstract Number 105

E-3*
MACROPHAGE ACTIVATION ASSOCIATED WITH DIASTOLIC DYSFUNCTION IN THE SIV/MACAQUE MODEL OF HIV CARDIAC DISEASE. 
K. Kelly, J. Karper, D. Bedja, S. Queen, K. Gabrielson, P. Tarwater, R. Adams, and J. Mankowski
Keyword: Cardiovascular System, Abstract Number 111

E-4
GNOTOBIOTIC PIGLET MODEL OF SHIGELLOSIS. 
K. Jeong, Q. Zhang, J. Nunnari, J. Mukherjee, A. Sheoran, N. Parry, A. Donohue-Rolfe, and S. Tzipori
Keyword: Alimentary, Abstract Number 116

E-5*
EFFECT OF MEASLES VIRUS ON SECONDARY BACTERIAL INFECTION IN COTTON RAT MACROPHAGES. 
M. Carsillo and S. Niewiesk
Keyword: Infectious Disease, Abstract Number 117

E-6
ENHANCED NEUTROPHIL INFILTRATION DURING INFLUENZA INFECTION IN THE CHRONIC ETHANOL MOUSE MODEL. 
D.K. Meyerholz, M. Edsen, R.A. Coleman, R.T. Cook, and K.L. Legge
Keyword: Toxicologic Pathology, Abstract Number 118

E-7*
RECOGNITION OF DIFFERENT MYCOBACTERIA SPECIES AND MANNOSYLATED CELL WALL COMPONENTS BY COLLAGEN DELETION TRIMERIC SUBUNITS OF SURFACTANT PROTEIN D. 
T.K. Carlson, J.B. Torrelles, E.C. Crouch, and L.S. Schlesinger.
Keyword: Infectious Disease, Abstract Number 119

E-8*#
INVESTIGATING THE ROLE OF STAT3 ACTIVATION IN HUMAN AND CANINE OSTEOSARCOMA. 
S.L. Fossey, A.T. Liao, J. Lin, P.K. Li, and C.A. London
Keyword: Bone and Joint, Abstract Number 120

E-9
THE EFFECT OF COX-2 INHIBITORS ON THE GROWTH AND INVASION OF CANINE PROSTATE CANCER CELLS. 
C. M. Rice and B. LeRoy
Keyword: Reproductive System, Abstract Number 121

E-10
CHARACTERIZATION OF CD3+ AND CD79+ LYMPHOCYTE POPULATIONS IN NORMAL CANINE PROSTATE AND PROSTATE CARCINOMA SAMPLES. 
H. Sheppard and B. LeRoy
Keyword: Reproductive System, Abstract Number 122

E-11*
BONE MORPHOGENETIC PROTEIN SIGNALING IS ASSOCIATED WITH THE PROLIFERATION AND THE GROWTH OF TUMORS IN VIVO OF CANINE MAMMARY GLAND OSTEOSARCOMA CELLS. 
A. Kawabata, R. Yamaguchi, S. Tateyama, and K. Shirota
Keyword: Mammary, Abstract Number 123

E-12*#
A TRANSGENIC MOUSE MODEL OF PANCREATIC DUCTAL ADENOCARCINOMA. 
M.M. Schutten and E.P. Sandgren
Keyword: Liver and Pancreas, Abstract Number 124

E-13*
DEVELOPMENT OF AN MRI TECHNIQUE FOR QUANTIFYING THYMIC ATROPHY AND REGENERATION IN CATS.
L. Kuhnt, R. Jennings, W. Brawner, J. Hathcock, and C. Johnson
Keyword: Immune System, Abstract Number 125

E-14*
USE OF DELAYED-TYPE HYPERSENSITIVITY RESPONSES TO SCREEN NOVEL IMMUNOSUPPRESSIVE TRANS SIGNAL CONVERTER PROTEINS FOR THE TREATMENT OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE). 
S. Yellayi, B. Hilliard, J. Hecker, M. Ghazanfar, S.O" Neil, S. Westmoreland, and M.L. Tykocinski
Keyword: Nervous System, Abstract Number 126

E-15*
14-3-3 PROTEIN IN CSF REFLECTS SIV-MEDIATED SYNAPTIC DAMAGE.
K.L. Helke and J.L. Mankowski
Keyword: Nervous System, Abstract Number 127

E-16
CHARACTERIZATION OF THE PROSTAGLANDIN TRANSPORTER PGT AND EXPRESSION IN NORMAL TISSUES AND IN MAMMARY TUMORS IN DOGS. 
J. Pinard, S.K. Banu, N. Bouchard, D. Rannou, J. Sirois, and M. Doré.
Keyword: Mammary, Abstract Number 128

E-17
MUCOSAL EXPOSURE TO ALLOANTIGEN DECREASES VIRAL BURDEN IN SUBSEQUENT MUCOSAL CHALLENGE WITH CELL-ASSOCIATED FIV. 
S. Kumar, S. Leavell, B. Assogba, and M.J. Burkhard.
Keyword: Infectious Disease, Abstract Number 129

E-18
PATHOLOGY OF P47PHOX (Ncf1) NULL MICE WITH MACROPHAGE AND LYMPHOCYTE DYSFUNCTION AND CRYSTALLINE PNEUMONIA.  L.I. Cheng, J.M. Ward,  and S.H. Jackson
Keyword: Respiratory System, Abstract Number 130

E-19
RETINOYL BETA GLUCURONIDE HAS A SIGNIFICANT EFFECT ON mRNA EXPRESSION OF INNATE IMMUNE GENES IN H441 HUMAN ADENOCARCINOMA LUNG CELLS. 
R. Derscheid, A. Barua, J. Gallup, M. de Macedo, and M. Ackermann
Keyword: Respiratory System, Abstract Number 131

E-20*
MATERNAL ALCOHOL INGETSION REDUCES SP-A EXPRESSION AND CILIARY BEAT FREQUENCY IN PREMATURELY BORN LAMBS.  T. Lazic, T.A. Wyatt, M. Matic, J.M. Gallup, and M.R. Ackermann
Keyword: Respiratory System, Abstract Number 132

E-21
VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION IN PRE-TERM AND TERM OVINE LUNG. 
A.K. Olivier, J.M. Gallup, and M.R. Ackermann
Keyword: Respiratory System, Abstract Number 133

E-22*
A NOVEL METHOD FOR THE DETECTION OF PORCINE CIRCOVIRUS TYPE 2 REPLICATIVE DOUBLE STRANDED VIRAL DNA AND NON-REPLICATIVE SINGLE STRANDED VIRAL DNA IN TISSUE SECTIONS. 
A. Hamberg, S. Ringler, and S. Krakowka
Keyword: Infectious Disease, Abstract Number 134

E-23*
CANINE INFLUENZA VIRUS REPLICATES IN CANINE ALVEOLAR MACROPHAGES AND INDUCES TNF-ALPHA EXPRESSION. 
J.R. Powe, D. Mukhtyar, and W.L. Castleman
Keyword: Infectious Disease, Abstract Number 135

E-24*
MAREK’S DISEASE VIRUS INFECTION IN CHICKENS: A NATURAL MODEL FOR VZV-INDUCED EYE LESIONS. 
A.K.R. Pandiri, A.L. Cortes, and I.M. Gimeno
Keyword: Infectious Disease, Abstract Number 136

E-25
ACUTE RENAL FAILURE IN RHESUS MONKEYS (MACACA MULATTA) EXPERIMENTALLY-INFECTED WITH PLASMODIUM SPP. 
A. García, A. Moreno, E. Strobert, and M. Galinski
Keyword: Infectious Disease, Abstract Number 137

E-26*
FOWLICIDIN-1 PROTECTS MICE FROM SEPSIS INDUCED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS. 
Y.R. Bommineni, J. Alexander, S. Periasamy, J.W. Ritchey, and G. Zhang
Keyword: Infectious Disease, Abstract Number 138

E-27*
DECREASED CCL5 CORRELATES WITH HEIGHTENED SUSCEPTIBILITY TO MYCOBACTERIUM TUBERCULOSIS INFECTION, DELATED T CELL TRAFFICKING TO THE LUNGS AND POORLY ORGANIZED GRANULOMAS IN VIVO.
G.L. Beamer, D.K. Flaherty, B. Vesosky, and J. Turner
Keyword: Infectious Disease, Abstract Number 139

E-28*
GAMMA-DELTA T CELLS ARE ASSOCIATED WITH INITIAL GRANULOMA DEVELOPMENT AND ORGANIZATION IN A NEONATAL BOVINE MODEL OF MYCOBACTERIAL DISEASE. 
B.L. Plattner, R.T. Doyle, and J.M. Hostetter
Keyword: Infectious Disease, Abstract Number 140

E-29
EFFECT OF MONOCYCLINE ON CELL CYCLE PROGRESSION AND PROLIFERATION OF CD4+ PRIMARY BLOOD LYMPHOCYTES. 
A.K. Brice, L.M. Carruth, T. Voelker, S.A. Barber and M.C. Zink
Keyword: Immune System, Abstract Number 141

E-30*
ADIPONECTIN GENE EXPRESSION AND PROTEIN SECRETION ARE UNAFFECTED IN A HIGH-FAT FED, OBESE DOG MODEL. 
B. Brunson, D. Bedi, E. Plaisance, and R. Judd
Keyword: Cardiovascular System, Abstract Number 110

* Competitor for the ACVP Young Investigator Award
# Competitor for the 2007 Christopher T. Starost Memorial Oncology Scholarship