ACVP > 2006 ACVP Specialty Group Program

Chair: L. Tomlinson
Committee Members: A. Provencher-Bolliger (co-chair), K. Gabrielson,D.L. Hutto, M.W. Leach, and D.B. Tumas

1:40 p.m. – 2:00 p.m.
DOSE-RESPONSIVE TOXICOLOGIC PATHOLOGY FOLLOWING ADMINISTRATION OF RECOMBINANT HUMAN ACID SPHINGOMYELINASE TO ACID SPHINGOMYELINASE KNOCKOUT MICE
A. Vitsky, M. Hawes, P. Ewing, S. Ryan, J. Murray, C. Nickerson, L. Andrews, and B.L. Thurberg
Keyword: Toxicologic Pathology, Abstract Number 191

2:00 p.m. – 3:00 p.m.
Invited Speaker
Patterns of Pathobiologic Response to
Bioactivated Respiratory Toxicants: Relation to
Bioactivation and Detoxification Profiles
C.G. Plopper

3:30 p.m. – 4:30 p.m.
Invited Speaker
Integrating metabolism, genetics, and proteomics to unravel the mechanisms of chemical-induced nephrocarcinogenicity
S.S. Lau

4:30 p.m. – 4:45 p.m.+
CHRONIC SUBLETHAL MICROCYSTIN EXPOSURE RESULTS IN PROLIFERATION AND CHANGES IN MITOTIC GENE EXPRESSION IN HOMOZYGOUS p53 KNOCKOUT MICE.
S. Clark, S. Hooser, T. Ryan, and M. Davis
Keywords: Liver and Pancreas, Abstract Number 192

4:45 p.m.- 5:00 p.m.
GONADAL ATROPHY AND OXIDATIVE STRESS IN CORBICULA FLUMINEA (CLAMS) APPARENTLY DUE TO POLYCHLORINATED BIPHENYL (PCB) EXPOSURE
M. Law, W. Lehmann, and J. Levine
Keyword: Wildlife, Abstract Number 193

Toxicologic Pathology Specialty Group Session II

Tuesday, December 5, 2006
1:30 p.m. – 5:00 p.m.
(Vet. Path. Abstracts 191-215)

Chair: L. Tomlinson
Committee Members: A. Provencher-Bolliger (co-chair), K. Gabrielson,D.L. Hutto, M.W. Leach, and D.B. Tumas

1:40 p.m. – 2:00 p.m.
METABOLIC BASIS OF ACETAMINOPHEN-INDUCED METHEMOGLOBINEMIA IN DOGS AND CATS
S. McConkey and A. Cribb
Keyword: Toxicologic Pathology, Abstract Number 194

2:00 p.m. – 3:00 p.m.
Invited Speaker
The Application of Hematologic and Hematopoietic Toxicology Investigation to Pharmaceuticals Discovery
B. Car

3:30 p.m. – 4:30 p.m.
Invited Speaker
The NEURO-ENDO-HEMATOPOIETIC CONNECTION
A. Provencher-Bolliger

4:30 p.m. - 4:45 p.m.+
COMPARISON OF THE MAMMARY GLAND EFFECTS IN THE FEMALE RAT OF FOUR SELECTIVE ESTROGEN RECEPTOR MODULATORS AND DIHYDROTESTOSTERONE
J. Lucas, P. Snyder, S. Hooser, A. Peter, and D. Rudmann
Keyword: Reproductive System, Abstract Number 196

4:45 p.m. -5:00 p.m.
EVALUATION OF CIPROFLOXACIN EFFECT IN SERTOLI CELLS IN RATS
K. Arash
Keyword: Reproductive System, Abstract Number 197

Poster Presentations:

T-1	TOXICITY OF RABBITS DUE TO Solanum glaucophyllum: AN EXPERIMENTAL MODEL FOR ENZOOTIC CALCINOSIS P.A. Fontana, C.N. Zanuzzi, M.S. Gomar, C.G. Barbeito, E.L. Portiansky, and E.J. Gimeno. Keyword: Toxicologic Pathology, Abstract Number 198
T-2	RATS TREATED WITH CYCLES OF ORAL PHIP/HIGH-FAT DIET DEVELOP A BROADER SPECTRUM OF TUMORS THAN RATS TREATED WITH PHIP ALONE C.V. Loehr, R. Wang, K.A. Fischer, and R.H. Dashwood. Keyword: Toxicologic Pathology, Abstract Number 199
T-3*	APOPTOSIS IN THE BRAIN OF MOUSE FETUSES BY ETOPOSIDE ADMINISTRATION C. Nam, H. Yamauchi, H. Nakayama, and K. Doi. Keyword: Toxicologic Pathology, Abstract Number 200
T-4	MODEL FOR PROTEASOME INHIBITION ASSOCIATED PERIPHERAL NEUROPATHY L. Silverman, V. Csizmadia, V.J. Kadambi, R. DeCoster, A. Vynckier, B. Jortner, and C.L. Alden Keyword: Toxicologic Pathology, Abstract Number 201
T-5	USE OF FLUORESCENT MICROSCOPY TO ASSESS THE RELATIONSHIP OF INHIBITION OF GAP JUNCTIONAL COMMUNICATION AND TOXICITY IN RAT TESTES P. Caplazi, M. Albassam, S.J. Platz, and K.L. Kolaja. Keyword: Toxicologic Pathology, Abstract Number 202
T-6	AN EN-FACE METHOD FOR CELL PROLIFERATION ASSAY OF RAT HEART VALVES USING WHOLE-MOUNT CONFOCAL MICROSCOPY V. Sasseville, H. Fang, W. Freebern, M. Slade, J. Canale, S. Durham, and M. Mense. Keyword: Toxicologic Pathology, Abstract Number 203
T-7	IMMUNOBLOT ASSAY OF THE PHILIPPINE COBRA VENOM USING NAJA PHILIPPINENSIS MONOVALENT ANTIVENIN F.M. Malbas, R.C. Atancio, B.C. Cavo, C. Mendoza, M.C. Dancel, D.P. Arbilo, and S.H. Mohammad Keyword: Toxicologic Pathology, Abstract Number 204
T-8	INCIDENCE OF SPONTANEOUS MICROSCOPIC FINDINGS IN CB6F1-RASH2 TRANSGENIC MICE ON 26-WEEK CARCINOGENICITY STUDIES J.F. Lafond, W.I. Anderson, B.G. Boysen, C.A. Thompson, R.W. Perry, and R.K. Harris Keyword: Toxicologic Pathology, Abstract Number 205
T-9*	CHRONIC SUBLETHAL MICROCYSTIN EXPOSURE RESULTS IN PROLIFERATION AND CHANGES IN MITOTIC GENE EXPRESSION IN HOMOZYGOUS p53 KNOCKOUT MICE S. Clark, S. Hooser, T. Ryan, and M. Davis Keyword: Liver and Pancreas, Abstract Number 192
T-10	HISTOPATHOLOGY OF THE LIVER IN HUMAN HEPATOCYTE-TRANSPLANTED CHIMERIC MICE Y. Sato, H. Yamada, C. Tateno, K. Iwasaki, T. Yokoi, K. Yoshizato, and I. Horii Keyword: Liver and Pancreas, Abstract Number 206
T-11	CYTOTOXIC ACTIVITY ON LEUKEMIC LYMPHOCYTES BY LATICAUDA COLUBRINA, TROPIDOLAEMUS SP. AND NAJA PHILIPPINENSIS VENOM F.M. Malbas, R.C. Atancio, B.C. Cavo, C. Mendoza, M.C. Dancel, D.P. Arbilo, and S.H. Mohammad. Keyword: Cytology, Abstract Number 207
T-12	TISSUE SECTION MORPHOMETRY IS A SENSITIVE METHOD TO ASSESS MAMMARY GLAND DEVELOPMENT IN POSTPUBERTAL RATS N.L. Stedman, H.A. Harris, T. Wong, B.A. Carito, and M.W. Leach. Keyword: Mammary, Abstract Number 208
T-13	SUPERFICIAL NECROLYTIC DERMATITIS IN DOGS FOLLOWING DRUG-INDUCED HEPATOXICITY J-L. Le Net and H. Tournade Keyword: Skin, Abstract Number 209
T-14	RELATIONSHIP OF KETAMINE-INDUCED CARDIAC DEPRESSION AND MAGNESIUM HOMEOSTASIS S.J. Kim, M.H. Lee, J.W. Seol, S.Y. Park, I.S. Kim, N.S. Kim, S.Z. Kim, J.S. Kim, and H.S. Kang Keyword: Cardiovascular, Abstract Number 210
T-15	POSSIBLE DRUG-INDUCED IDIOSYNCRATIC IMMUNE MEDIATED HEMOLYTIC ANEMIA IN A CYNOMOLGUS MONKEY E. Polack, S. Parker, G. Baskin, G. Elliott, and R. Walker Keyword: Hematology, Abstract Number 211
T-16	ADVERSE EFFECT OF ENVIRONMENT ENRICHMENT IN GENETICALLY ENGINEERED MICE D.C. Haines, D. Logsdon, and P. Gorelick Keyword: General topic, Abstract Number 212
T-17	EFFECT OF EXERCISE ON CERIVASTATIN-INDUCED SKELETAL MUSCLE TOXICITY IN RATS J. Seachrist, C-M. Loi, M. Evans, K. Criswell, and C. Rothwell. Keyword: Muscle, Abstract Number 213
T-18	EFFECTS OF TWO NOVEL SELECTIVE ESTROGEN RECEPTOR MODULATORS, RALOXIFENE, TAMOXIFEN, AND ETHINYL ESTRADIOL ON THE UTERUS, VAGINA AND BREAST IN OVARIECTOMIZED CYNOMOLGUS MONKEYS (MACACA FASCICULARIS) P. Sikoski, T.C. Register, C.J. Lees, S. Lundeen, J. Hutchison, K.H. Brown, and J.M. Cline Keyword: Reproductive System, Abstract Number 214
T-19*	COMPARISON OF THE MAMMARY GLAND EFFECTS IN THE FEMALE RAT OF FOUR SELECTIVE ESTROGEN RECEPTOR MODULATORS AND DIHYDROTESTOSTERONE J. Lucas, P. Snyder, S. Hooser, A. Peter, and D. Rudmann Keyword: Reproductive System, Abstract Number 196
T-20	EVALUATION OF CIPROFLOXACIN EFFECT IN SERTOLI CELLS IN RATS K. Arash Keyword: Reproductive System, Abstract Number 19
T-21*	CORRELATION BETWEEN BROILER AFLATOXICOSIS AND EUROPEAN PRODUCTION EFFICIENCY FACTORS A.M. Shareef, O.S. Beyon, and T.S. Quibeh Keyword: Avian, Abstract Number 215
T-22	COMPARATIVE ASSESSMENT OF THROMBOPOIESIS IN RATS AND DOGS WITH THE ADVIA 120 ANALYZER AND BY DETECTION OF RETICULATED PLATELETS A. Pankraz, N. Bauer, A. Moritz, A. Provencher-Bolliger, and D. Roman Keyword: Hematopoietic System, Abstract Number 195

^*Competitor for ACVP Young Investigator Award