ACVP > 2006 ACVP Specialty Group Program

1:30 p.m.-5:00 p.m.
Experimental Disease Specialty Group Session I
(Vet. Path. Abstracts 98-151)

Chair: L. Diehl
Committee Members: M. Ackermann (co-chair), M. Behr, K. Boyd, D. Gardner, and D. Bouley

1:30 p.m.-2:15 p.m.
Invited Speaker
The Endothelial Cell in Vascular Remodeling: Pathology of the Microenvironment
D.W. Wilson

2:15 p.m.-2:30 p.m.
ENDURANCE EXERCISE TRAINING INDUCES CARDIAC MICROVASCULAR LIPOPROTEIN LIPASE IN MALE PIGS
J.R. Turk, J. Casati-Zajicek, T.W. Zderic, D.G. Hamilton, and M.T.Hamilton
Keyword: Cardiovascular, Abstract Number 98

2:30 p.m.-2:45 p.m.
CORRELATING NON-INVASIVE IN VIVO IMAGING METHODS TO HISTOPATHOLOGY IN MOUSE MODELS
K. Gabrielson, D. Bedja, T. Cooper, D. Kass, E. Takimoto, H. Dietz, G. Smok, B. Tsui and D. Huso
Keyword: Cardiovascular, Abstract Number 99

2:45 p.m.-3:00 p.m.
PNEUMOCYSTIS PNEUMONIA IN XSCID DOGS TREATED WITH LOW-DOSE EX VIVO RETROVIRAL GENE THERAPY
A. Durham, T. Van Winkle, and P. Felsburg
Keyword: Immune System, Abstract Number 100

3:30 p.m.-3:45 p.m.
IN SITU HYBRIDIZATION INVESTIGATION ON THE PATHOGENESIS OF THE HPAI H5N1 EXPERIMENTAL INFECTION IN PEKIN DUCKS
M. Vascellari, A. Granato, L. Basilicata, L. Trevisan, and F. Mutinelli
Keyword: Avian, Abstract Number 101

3:45 p.m.-4:00 p.m.
MUCOSAL ADMINISTRATION OF PNEUMOVIRAL VACCINES: INSIGHTS FROM BOVINE AND MURINE MODELS
J.A. Ellis, S. Gow, K.H. West, C. Waldner, J.B. Domachowske, and H.F. Rosenberg
Keyword: Respiratory System, Abstract Number 102

4:00 p.m.-4:30 p.m.PATHOLOGY OF AEROSOLIZED RABBITPOX VIRUS INFECTION IN RABBITS
D.K. Nichols, A. Nalca, and C.J. Roy
Keyword:Infectious Disease, Abstract Number 103

4:15 p.m.-5:00 p.m.
Invited Speaker
Airway generation-specific remodeling, immune and inflammatory cells and cytokines in allergen- challenged rhesus monkeys
D.M. Hyde

Experimental Disease Specialty Group Session II

Tuesday, December 5, 2006
1:30 p.m.-5:00 p.m.
(Vet. Path. Abstracts 98-151)

Chair: L. Diehl
Committee Members: M. Ackermann (co-chair), M. Behr, K. Boyd, D. Gardner, and D. Bouley

1:30 p.m.-2:15 p.m.
Invited Speaker
New Mouse Models of Retinoblastoma
M.A. Dyer

2:15 p.m.-2:30 p.m.
MALE PREDISPOSITION TO HEPATITIS-ASSOCIATED LIVER CANCER IS DEVELOPMENTALLY IMPRINTED IN MICE
A.B. Rogers, E.J. Theve and J.G. Fox
Keyword: Liver and Pancreas, Abstract Number 104

2:30 p.m.-2:45 p.m. NOTCH PATHWAY FACTORS IN CANCER AND ALZHEIMER'S DISEASE
C. Brayton, T. Li, T. Gluckman, B. Simons, S. Trembley, and N. Forbes
Keyword: None of the Above, Abstract Number 105

2:45 p.m.-3:00 p.m. A GERM-FREE MOUSE MODEL OF RENAL DISEASE DUE TO ENTEROHEMORRHAGIC ESCHERICHIA COLI
K.A. Eaton, T.S. Whittam, G.J. Francis, V. Wu, and L. Benson
Keyword: Infectious Disease, Abstract Number 106

3:30 p.m.-3:45 p.m.
FIV LATENCY: IMPLICATIONS OF HOST FACTORS AND DOSE RESPONSES
B.D. Assogba and M.J. Burkhard
Keyword: Infectious Disease, Abstract Number 107

3:45 p.m.-4:00 p.m.
BACKGROUND STRAIN AND NEUROENDOCRINE TUMOR DEVELOPMENT IN THE TRAMP MODEL OF PROSTATE CANCER
S. Couto, T. Chiaverotti, A. Donjacour, R. Cardiff, G. Cunha, and A. Balmain
Keyword: Reproductive System, Abstract Number 108

4:00 p.m.-4:15 p.m.
CORRELATION OF HISTOPATHOLOGY OF MINIMALLY INVASIVE THERMAL OR CRYOABLATION CANCER TREATMENTS WITH CONTRAST-ENHANCED MR IMAGES IN NORMAL DOG PROSTATES
D.M. Bouley, B. Daniel, K. Butts Pauly, E. Liu, C. Diederich, W. Nau, and G. Sommer
Keyword: Reproductive System, Abstract Number 109

4:15 p.m.-5:00 p.m.
Invited Speaker
Studies for cross-validating tumor vs. response-related clinically relevant serum biomarker proteins in pre-clinical models
R.M. Simpson

Poster Presentations:

E-1	CENTRALIZED RESOURCES DETAILING THE GENOTYPE, PHENOTYPE AND AVAILABILITY OF GENETICALLY ENGINEERED MICE A.J. O’Hara, A.B. Jenson, P. Schofield, S. Ghim, Y. Sun, J.T. Eppig and J.P. Sundberg Keyword: Skin, Abstract Number 110
E-2	PRECLINICAL PROGRAM FOR ALOPECIA AREATA DRUG EFFICACY SCREENING K.E. Koehler, C. French, K.A. Silva, L.E. King, V. Kalabokes, and J.P. Sundberg Keyword: Skin, Abstract Number 111
E-4*#	THE ROLE OF SLUG IN UVR-INDUCED SKIN CARCINOGENESIS K.M. Newkirk, A.E. Parent, and D.F. Kusewitt Keyword: Skin, Abstract Number 11
E-5*#	EMT AT THE INVASIVE FRONT OF CUTANEOUS SQUAMOUS CELL CARCINOMAS S. Fossey, K. Newkirk, A. Parent, and D. Kusewitt Keyword:Skin, Abstract Number 114
E-6*#	POLYMORPHISMS IN THE DNA REPAIR GENE PRKDC MAY CONFER SUSCEPTIBILITY TO RADIATION-INDUCED MAMMARY CANCER IN MICE L. Ramaiah, M.M. Weil, C. Desaintes, and R.L. Ullrich Keyword: Mammary, Abstract Number 115
E-7	CHIBBY KNOCKOUT MICE: A POSSIBLE MODEL OF SHWACHMAN-DIAMOND SYNDROME? P.M. Treuting, V.A. Voronina, L. Hajjar, K-I. Takemaru, and Randall Moon Keyword: Liver and Pancreas, Abstract Number 116
E-8	COLORECTAL DYSPLASIA AND CANCER PHENOTYPES IN MOUSE MODELS OF BACTERIAL-INDUCED CARCINOGENESIS P. Treuting, H. Bielefeldt-Ohmann, B. Iritani, and L. Maggio-Price Keyword: Alimentary, Abstract Number 117
E-9	SUBCONGENIC ANALYSIS OF Cdcs1 A MAJOR COLITIS SUSCEPTIBILITY MODIFIER IN MICE E. Leiter, J. Beckwith, L. Petell, B. King, J. Affourtit, D. Shaffer, D. Roopenian, and J.P. Sundberg Keyword: Alimentary, Abstract Number 118
E-10	THE EFFECTS OF CLOSTRIDIUM PERFRINGENSENTEROTOXIN ON LIGATED INTESTINAL LOOPS OF RABBITS F.A. Uzal, J.G. Smedley, III, J. Saputo, M.E. Fernandez Miyakawa and B.A. McClane Keyword: Alimentary, Abstract Number 119
E-11	A CATHETERIZED PIGLET MODEL FOR ADMINISTERING STAGE-APPROPRIATE THERAPIES FOR STAPHYLOCOCCAL ENTEROTOXIN-B (SEB) INDUCED LETHAL TOXICSHOCK S. Mani, W.S. Flournoy, G.D. Coleman and M. Jett Keyword: Toxicologic Pathology, Abstract Number 120
E-12	AN EXPERIMENTAL RABBIT MODEL OF CAVITARY TUBERCULOSIS K.L. Helke, M.A. Yoder, J.L. Mankowski, Y.C. Manabe, and W.R. Bisha Keyword: Infectious Disease, Abstract Number 121
E-13	LYMPHOCYTE RESPONSES AND MACROPHAGE KILLING OF INTRACELLULAR MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS FOLLOWING VACCINATION IN NEONATAL CALVES. B.L. Plattner, L. Lei, W. Zhang, and J. Hostetter Keyword: Infectious Disease, Abstract Number 122
E-14	A HIGH CELL PASSAGES CANINE CORONAVIRUS VACCINE FOR THE IMMUNIZATION OF DOGS A. Pratelli Keyword: Infectious Disease, Abstract Number 123
E-15*	A STUDY OF APOPTOSIS IN SPLEEN AND BURSA FABRICIUS OF INFECTED CHICKENS BY INFECTIOUS BURSAL DISEASE VIRUS BY USING ELECTRONIC MICROSCOPE A. Zakeri, M.H. Bozorgmehri, and S. Zakeri Keyword: Infectious Disease, Abstract Number 124
E-16*	WEST NILE ENCEPHALITIS: SEQUENTIAL HISTOPATHOLOGICAL AND IMMUNOLOGICAL EVENTS IN A MURINE MODEL OF INFECTION D. Garcia-Tapia, D.E. Hassett, G.C. Johnson, W.J. Mitchell, and S.B. Kleiboeker Keyword: Infectious Disease, Abstract Number 125
E-17*	#NFkappaB AND BCL3 COOPERATIVELY TRANSACTIVATE THE PARATHYROID HORMONE- RELATED PROTEIN PROMOTER IN ADULT T-CELL LEUKEMIA/LYMPHOMA M.V.P. Nadella, W.P. Dirksen, K.S. Nadella, S. Shu, V. Richard, and T.J. Rosol Keyword: Infectious Disease, Abstract Number 126
E-18*#	YEAST TWO-HYBRID ANALYSIS OF PROTEIN INTERACTIONS INVOLVING THE HTLV-1 ACCESSORY PROTEIN P30II L.M. Millward, A.J. Phipps, A. Chang, N. Sabo, and M.D. Lairmore Keyword: Infectious Disease, Abstract Number 127
E-19*#	DEVELOPMENT OF A XENOGRAFT MOUSE MODEL OF HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE 1 ASSOCIATED ADULT T CELL LEUKEMIA/LYMPHOMA FOR USE IN PRECLINICAL EFFICACY AND THERAPEUTIC STUDIES B. Zimmerman, C. Parrula, S. Niewiesk, and M.D. Lairmore Keyword: Infectious Disease, Abstract Number 128
E-21*	MORPHOLOGIC AND INFLAMMATORY RESPONSE ANALYSIS OF SALMONELLA-INDUCED ENTERITIS IN CALVES WITH BOVINE LEUKOCYTE ADHESION DEFICIENCY J. Nunes, J.F. Figueiredo, S. Lawhon, C. Rosetti, S. Khare, and L.G. Adams Keyword: Infectious Disease, Abstract Number 130
E-22*	COMPLEMENT PROTEIN C3 DEPOSITION ENHANCES PHAGOCYTOSIS OF BACILLUS ANTHRACIS SPORES BY MACROPHAGES C. Premanandan, C. Storozuk, M.D. Lairmore and A.J. Phipps Keyword: Infectious Disease, Abstract Number 131
E-23*	EXACERBATION OF DSS INDUCED INTESTINAL INFLAMMATION FOLLOWING INOCULATION OF BALB/C, BUT NOT SCID, MICE WITH MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS C. Johnson, W. Zhang, and J. Hostetter Keyword: Infectious Disease, Abstract Number 132
E-24*	ROLE OF AIDA-I ADHESIN IN PATHOGENESIS OF E. COLI INDUCED DIARRHEA IN PIGS M. Ravi, M. Ngeleka, S-H. Kim, C.L. Gyles, F. Berthiaume, M. Mourez, D.M. Middleton, and E.Simko Keyword: Infectious Disease, Abstract Number 133
E-25*	THE HISTOLOGICAL STUDIES OF BAT RETINA T. Omatsu, S. Sekiguchi, M. Suzuki, Y. Ishii, S. Kyuwa, and Y. Yoshikawa Keyword: Eye and Ear, Abstract Number 134
E-26	RETINAL CELL SUBTYPES ARE DIFFERENTIALLY AFFECTED IN SHEEP WITH SCRAPIE J. Greenlee, J. Smith, A. Hamir, and M.H. West Greenlee Keyword: Eye and Ear, Abstract Number 135
E-27	EFFECT OF LACTOBACILLUS SUPERNATANTS ON LEPTIN PRODUCTION IN RODENTS R. Sousa, J. Zhang, S. Lewis, O. Li, and J. Halper Keyword: Nervous System, Abstract Number 136
E-28	BLOOD IONIZED MAGNESIUM AND CALCIUM IN EXPERIMENTAL MYOCARDIAL INFARCTION AND CARDIAC HYPERTROPHY S.J. Kim, M.H. Lee, H.J. Tae, I.S. Kim, S.Y. Park, N.S. Kim, S.Z. Kim, J.S. Kim, and H.S. Kang Keyword: Cardiovascular, Abstract Number 137
E-29	BLOOD IONIZED MAGNESIUM AND CALCIUM IN EXPERIMENTAL OSTEROARTHRITIS IN DOGS S.J. Kim, M.H. Lee, H.B. Lee, N.S. Kim, I.S. Kim, S.Y. Park, S.Z. Kim, J.S. Kim, and H.S. Kang Keyword: Bone and Joint, Abstract Number 138
E-30	BLOOD IONIZED MAGNESIUM AND CALCIUM IN RESPIRATORY AND METABOLIC ALKALOSIS M.H. Lee, S.J. Kim, N.S. Kim, I.S. Kim, S.Y. Park, S.Z. Kim, J.S. Kim, and H.S. Kang Keyword: Clinical Chemistry, Abstract Number 139
E-31	EXPRESSION OF NITRIC OXIDE SYNTHASE ISOFORMS IN NEONATAL TRANSGENIC PIG LUNGS J.R. Turk, M. Kommareddy, J. Casati-Zajicek, R. Prather, E. Rucker, and M.H. Laughlin Keyword: Respiratory System, Abstract Number 140
E-32	AN OVINE MODEL FOR DELIVERY OF ALCOHOL AND NICOTINE DURING GESTATION T. Lazic, M. Matic, B. Grubor, J.M. Gallup, P.M. Imerman, D.K. Meyerholz, and M.R. Ackermann Keyword: Respiratory System, Abstract Number 141
E-33*	SUSCEPTIBILTY AND EXTENT OF HUMAN RESPIRATORY SYNCYTIAL VIRUS STRAIN A2 INFECTION IN NEWBORN LAMBS A.K. Olivier, J.M. Gallup, S.M. Varga, and M.R. Ackermann Keyword: Respiratory System, Abstract Number 142
E-34*	SWINE AUTO-ANTI-IDIOTYPIC ANTIBODY SPECIFIC FOR ANTIBODIES AGAINST GP5 ANTIGEN OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS ELICITS SPECIFIC IMMUNE RESPONSE IN MICE M. Ameri, E-M. Zhou, and Z. Jiang Keyword: Immune System, Abstract Number 143
E-35*	THE ROLE OF B CELLS IN THE CELL-MEDIATED IMMUNE RESPONSE TO LEISHMANIA AMAZONENSIS K.N. Gibson-Corley, R.M. Mukbel, C.A. Petersen, and D.E. Jones Keyword: Immune System, Abstract Number 144
E-36*	ESTRIOL PRODUCES REGULATORY DCS THAT PROTECT AGAINST EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS T. Papenfuss, N. Powell, M. McClain, I. Gienapp, T. Shawler, and C. Whitacre Keyword: Immune System, Abstract Number 145
E-37*	AUGMENTATION OF CRP AND MMP-9 IN ADVANCED ATHEROSCLEROTIC LESIONS IN CYNOMOLGUS MACAQUES (MACACA FASCICULARIS) J.A. Cann, J.M. Cline, R.W. St. Clair, and J.K. Williams Keyword: Cardiovascular, Abstract Number 146
E-38*	MODULATION OF RAS-MAPK PATHWAY PROVIDES SURVIVAL BENEFIT IN CONDITIONAL CARDIAC SPECIFIC H-RAS-V12 MOUSE MODEL OF HUMAN CARDIOMYOPATHY P.L. Martin, E. Spehalski, M.J. Hoenerhoff, S. Hoover, J.M. Rozenburg, C. Vinson, and R.M. Simpson Keyword: Cardiovascular, Abstract Number 147
E-39*	UBIQUITIN C-TERMINAL HYDROLASE L1 IN MICE OOCYTES FUNCTIONS BLOCK TO POLYSPERMY S. Sekiguchi, J. Kwon, H. Hamasaki, S. Ichinose, M. Hideshima, Y. Ishii, S. Kyuwa, K. Wada, and Y. Yoshikawa. Keyword: Reproductive System, Abstract Number 148
E-40	EFFECTS OF CALCITRIOL AND DIHYDROTESTOSTERONE (DHT) ON ARGININE ESTERASE (AE) ACTIVITY AND VITAMIN D RECEPTOR (VDR) EXPRESSION IN EXPLANTS OF CANINE PROSTATE TISSUE T. Kaewsakhorn, C.C. Capen, and N. Inpanbutr Keyword: Reproductive System, Abstract Number 149
E-41	DEVELOPMENT OF A MOUSE MODEL TO EVALUATE THE EFFECTS OF CALCITRIOL, SEOCALCITOL AND PIROXICAM ON CANINE URINARY BLADDER CANCER T. Kaewsakhorn, W.C. Kisseberth, C.C. Capen, and N. Inpanbutr Keyword: Urinary System, Abstract Number 150
E-42	BLOCKADE OF PDGF AND PTHRP AMELIORATES OSTEOBLAST STIMULATION BY NORMAL AND NEOPLASTIC CANINE PROSTATE IN A RAT CALVARIA MODEL S. Hutsell, A Painter, and B. LeRoy Keyword: Urinary System, Abstract Number 151

*Competitor for the ACVP Young Investigator Award
# Competitor for 2006 Christopher T. Starost Memorial Oncology Scholarship