ACVP > 2005 Pre- and Post-Meeting Workshops

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2005 Pre- and Post-Meeting Workshops

Special Workshop Offering

Division of Animal Clinical Chemistry (DACC) Fall Meeting
Assessment of Reproductive Effects in Animals – A Primer for Clinical Pathologists
Friday, December 2, 2005
8:00 a.m.-5:00 p.m.

Male Reproduction: What Happens, How Do We Measure It and What’s New?
Female Reproduction: What Happens, How Do We Measure It and What’s New?
Current Reproductive Paradigms in Industry
Case Study: Use of Inhibin B as a Marker of Spermatogenic Dysfunction
Risk Assessment and Reproductive Changes in Drug Development
Hematology and Clinical Chemistry in Pregnant Animals
Assessment of Reproductive Hormones in Multiple Species: Methods and Validation Issues

Members of ASVCP and ACVP can attend this workshop at the DACC member rate, which is $85.00. Registration for this workshop is available online at the DACC website – http://www.aacc.org/meetings/anim05fall/default.stm.

Pre-Meeting Workshops

Saturday, December 3, 2005
Three concurrent workshops are being held on Saturday and available for a separate fee.
To register for the workshops listed below, click on “registration” at www.acvp.org/meeting/.

ASVCP Pre-Meeting Workshop
The Role of Clinical Pathology Parameters in the Integrated Assessment of Drug-Induced Hepatoxicity, Immunotoxicity, and Renal Toxicity in Preclinical Studies
Session Chair: Laura I. Boone, DVM, PhD*
Saturday, December 3, 2005
8:00 a.m.-5:00 p.m.

Workshop Fee: $250

Identifying drug-induced toxicity in preclinical studies is a critical process in drug development. For preclinical safety studies, the veterinary clinical pathologist has the obligation to provide an integrated evaluation of clinical pathology data, the results of the histological evaluation, and all other study data to identify drug-induced injury and provide an assessment of the potential risk of similar toxicity in human patients.This pre-meeting workshop will review the appropriate clinical pathology parameters to include in preclinical studies and guiding principles for interpretation of these parameters for the identification of potential drug-induced toxicity in the liver, kidney, and lymphoid tissues (i.e., the spleen, draining lymph nodes, thymus, and bone marrow). Although multiple species (i.e., rat, dog, and non-human primate) are routinely utilized as animal models in preclinical studies, this workshop will predominantly focus on the rat model. The morning and early afternoon sessions of this workshop will focus on the identification of drug-induced hepatotoxicity; the remainder of the afternoon session will address the identification of drug-induced immunotoxicity and renal toxicity. Organ-specific case studies and discussion of novel biomarkers and assays will be included in the workshop.

The Interpretation of Clinical Pathology Parameters in the Integrated Assessment of Drug-Induced Toxicity
Recommended Liver Tests for the Detection of Hepatic Pathology in Toxicology Studies
Xenobiotic-Induced Noncholestatic Acholuric Jaundice in Nonhuman Primates
You Want to Measure What??!: Tests Not Routinely Used in Preclinical Studies
Novel Biomarkers in Preclinical Studies
Correlation of Serum ALT Activity and Liver Histological Changes in Rodent Preclinical Studies
Case Presentations of Hepatic Toxicity
Something Old, Something New: Traditional and Novel Biomarkers in Renal Injury
What Do Clinical Pathologists and Neutrophils have in Common: They’re Both the First Line of Defense in Immunotoxicology

C.L. Davis Foundation Pre-Meeting Workshop
Identification of Protozoan and Metazoan Parasites in Tissue Sections: A Practical Guide
Saturday, December 3, 2005
8:00 a.m.-5:00 p.m.

Workshop Fee: $175

Protozoan and metazoan parasites are often discovered in biopsies. Frequently, proper identification of the parasite is required to initiate appropriate treatment or herd-health measures. This course will provide the basic information necessary to recognize and identify parasites. This will be accomplished with three illustrated presentations: the identification of protozoan and metazoan parasites in histological section; methods in the preservation of gross parasites for morphological identification; and diagnostic case studies. At the end of the symposium attendees will have a better understanding of parasitological procedures needed to process intact organisms; and the range of minute, morphological characteristics used to identify parasites in histological section. As a bonus, all registrants will receive a copy of the two texts: “An Atlas of Protozoan Parasites in Animal Tissue” and “An Atlas of Metazoan Parasites in Animal Tissues,” authored by Dr. C.H. Gardiner, et al.

ILSI/HESI/ACVP Pre-Meeting Workshop
Current Issues in Neuropathology
Saturday, December 3, 2005
8:00 a.m.-5:00 p.m.

Progress continues to be made in our understanding of the pathogenesis of nervous system diseases, mainly due to the increasingly rapid improvement in neurobiology research and the advent of new technology. This neuropathology seminar will provide a coordinated discussion of emerging methodologies that are used to assess neural structure, function, cellular interactions and mechanisms of disease in the central and peripheral nervous systems of adult and developmental studies, in conjunction with a broad consideration of current challenges and opportunities that will face pathologists in this field. As scientists and diagnosticians, we are incorporating new technologies such as neuroimaging, proteomics, and cerebrospinal fluid biomarkers, and utilizing animal models of aging and neurodegenerative diseases. These exciting advances in neuropathology are motivating influences for updating pathologists with new approaches to better understand biologic and mechanistic responses in the complex nervous system.

This is the eighth in a series of seminars presented by the ILSI Health and Environmental Sciences Institute (HESI) and other components of the International Life Sciences Institute in conjunction with the American College of Veterinary Pathologists.

To register for this workshop contact: Eric Moore, ILSI, One Thomas Circle, NW, 9th Floor, Washington, DC, 20005, USA; Telephone: +1-202-659-0074; Facsimile: +1-202-659-3859; Email: emoore@ilsi.org.

Post-Meeting Workshops

Wednesday, December 7, 2005
Workshop Fees:

$165 (members and non-members)
$100 (resident, fellow, graduate students)
$ 50 (professional students – a limited number of enrollments are available for students)

Post-Meeting Workshop I
Systemic Pathology of Fish
(attendance limited to 40 people–to be held at the New England Aquarium–transportation provided)
Session Chair: Mac Law, DVM, PhD*
Wednesday, December 7, 2005
1:00 p.m.-5:30 p.m.

Veterinary pathologists are increasingly encountering fish specimens as both aquaculture and the use of fish models in safety assessment and research grow in importance. This workshop will focus on diseases of common fish species using a systems approach, including detailed discussions of skin and gill pathology, as well as hepatic, cardiovascular, hematopoietic, ocular, and renal systems. Handouts and a tour with New England Aquarium veterinarian, Scott Weber, are included in the registration fee.

Tour of the New England Aquarium
Introduction and Fish Necropsy Techniques: From the Field to the Lab
Skin Pathology I
Skin Pathology II and Gill Pathology I
Gill Pathology II, Hepatic, and Cardiovascular Systems
Spleen/Thymus, Eye, and Renal Pathology

Post-Meeting Workshop II
Pathology of Genetically-Engineered Mice
Session Chair: Cory F. Brayton, DVM, DACLAM*
Wednesday, December 7, 2005
1:00 p.m.-5:00 p.m.

This workshop aims to provide useful information and resources for pathologists who are interested in phenotyping or have become involved in phenotyping of genetically engineered mice (GEM) by choice, or not. Emphasis will be on background pathology (phenotypes) of different mouse strains, pathology (phenotypes) related to environmental factors especially infectious agents, use of clinical pathology evaluations in phenotyping, and diagnosis of GEM neoplasia, whether related (primarily) to intended genetic manipulations or to other factors.

Muromics, Pathologic and Scientific Considerations for Phenotyping GEM and Other Mice
Spontaneous Pathology of Common Mouse Strains and GEM’s
Clinical Pathology of Mice and GEM’s
Health Surveillance and the Prevalence and Influence of Infectious Agents on GEM’s
Pathway Pathology in GEM: Tumor Diagnosis and Nomenclature

*ACVP Diplomate

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