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2004 Toxicologic Pathology Platform and Posters

Sunday, November 14, 2004

1:30 p.m.-5:00 p.m.
Toxicologic Pathology Specialty Group Session I
(Vet. Path. Abstracts 158-185)
Theme: Toxicologic Pathology of Organelles - I
Chair: Bruce D. Car
Committee members: M. Leach, D. Hutto, R. Frank, D. Tumas, M. Tomlinson

Platform Presentations:

1:30 p.m. - 1:40 p.m.
Invited Speaker
AN INTRODUCTION TO THE TOXICOLOGIC PATHOLOGY OF ORGANELLES: PROTEASOMES, MITOCHONDRIA, PEROXISOMES, LYSOSOMES AND OTHERS AS MOLECULAR TARGETS
Dr. Bruce D. Car

1:40 p.m. - 2:30 p.m.
Invited Speaker
PROTEASOMAL TOXICITY: PATHOGENESIS OF HIV PROTEASE INHIBITOR-INDUCED DYSLIPIDEMIA AND LIPODYSTROPHY
Dr. Oliver P. Flint

2:30 p.m. - 2:45 p.m.
PROTEASOME INHIBITORS DO NOT INDUCE INCREASED ENDOGENOUS PRION PROTEIN (PRP) OR THE FORMATION OF PROTEINASE K-RESISTANT PRP IN MURINE AND HUMAN NEURONAL CELL LINES IN VITRO
V. Sasseville, A. Raczynski, V. Csizmadia, W. Riordan, J. Ironside, and P. Bouchard
Keyword: Toxicologic Pathology, Abstract #158

2:45 p.m. - 3:00 p.m.
STRATEGY FOR HAZARD ASSESSMENT AND RISK MANAGEMENT OF DRUG-INDUCED PHOSPHOLIPIDOSIS
L. Chatman, D. Morton, S. Anway, and S. Eustis
Keyword: Toxicologic Pathology, Abstract #159

3:00 p.m. - 3:30 p.m.
REFRESHMENT BREAK - VISIT POSTERS AND EXHIBITS!

3:30 p.m. – 4:15 p.m.
Invited Speaker
NONCLINICAL DISCOVERY AND DEVELOPMENT FOR BORTEZOMIB (VELCADE): A PROTEASOME INHIBITOR FOR THE TREATMENT OF CANCER
Dr. Page Bouchard

4:15 p.m. - 4:30 p.m.
SCREENING STRATEGIES IN HIT-TO-LEAD AND EARLY LEAD OPTIMIZATION WITH GOOD PREDICTIVITY FOR DEVELOPMENT LIMITING SIDE EFFECTS AND TOXICITY
C. Alden, V. Sasseville, J. Lane, V. Kadambi, P. Bouchard, and P. Smith
Keyword: Toxicologic Pathology, Abstract #160

4:30 p.m. - 4:45 p.m.
IDENTIFICATION AND CHARACTERIZATION OF TESTICULAR TOXICANTS IN RATS WITH DNA MICROARRAYS
R. Ciurlionis, K. Whitney, J. Waring, I. Milicic, M. Strakhova, and E. Blomme
Keyword: Reproductive System, Abstract #161

4:45 p.m. - 5:00 p.m.
INVESTIGATION OF HEMATOTOXICITY IN DOGS AND RATS WITH PSEUDO PELGER-HUËT ANOMALY
A. Provencher Bolliger, S. Hintermann, A. Hartmann, and L. O’Rourke
Keyword: Hematopoietic System, Abstract #162

Tuesday, November 16, 2004

1:30 p.m.-5:00 p.m.
Toxicologic Pathology Specialty Group Session II
(Vet. Path. Abstracts 158-185)
Theme: Toxicologic Pathology of Organelles - II
Chair: Bruce D. Car
Committee members: M. Leach, D. Hutto, R. Frank, D. Tumas, M. Tomlinson

Platform Presentations:

1:30 p.m. - 1:40 p.m.
Invited Speaker
INTRODUCTION: NOVEL THERAPEUTIC TARGETS AND THEIR POTENTIAL TOXICITY TO ORGANELLES
Dr. Daniel B. Tumas

1:40 p.m. - 2:30 p.m.
Invited Speaker
PEROXISOMAL PROLIFERATION, PPARa AGONISTS AND HEPATOCARCINOGENESIS
Dr. Russell C. Cattley

2:30 p.m. - 2:45 p.m.
CANCER PHENOTYPE BIOMARKERS IN HUMAN XENOGRAFT BEARING MICE BY SERUM PROTEOMIC PATTERN RECOGNITION USING SURFACE ENHANCED LASER DISORPTION AND IONIZATION MASS SPECTROSCOPY ANALYSIS
R.M. Simpson, L.A. Liotta, V. Rajapakse, V. Fusaro, M. He, C. Shaw, S. Ross, J.C. Barrett, and E.F. Petricoin 3rd
Keyword: Clinical Chemistry, Abstract #163

2:45 p.m. - 3:00 p.m.
IMMUNOSUPPRESSIVE-RELATED LYMPHOPROLIFERATIVE DISORDER (IRLD) OF MACAQUES AS A MODEL OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER (PTLD)
J. Markovits, H. Duan, L. O’Rourke, J. Omerza, and P. Sahota
Keyword: Primates, Abstract #164

3:00 p.m. - 3:30 p.m.
REFRESHMENT BREAK - VISIT POSTERS AND EXHIBITS!

3:30 p.m. - 4:15 p.m.
Invited Speaker
REVIEW OF MECHANISMS OF MITOCHONDRIAL TOXICITY
Dr. Susan G. Emeigh-Hart

4:15 p.m. - 4:30 p.m.
ANALYSIS OF MICRO-DISSECTED MESENTERIC VASCULAR ELEMENTS FROM RATS GIVEN SKF-82526 (FENOLDOPAM): TEMPORAL GENE EXPRESSION USING AFFYMETRIX GENECHIP®
M.S. Scicchitano, D.A. Dalmas, Y. Chen, H.C. Thomas, P. Narayanan, L.A. Tierney, R.W. Boyce, S. Clark, and L.W. Schwartz
Keyword: Cardiovascular, Abstract #165

4:30 p.m. - 4:45 p.m.
CARDIAC GENE PROFILING IN SPRAGUE-DAWLEY RATS ASSOCIATED WITH MINIMALLY INVASIVE SURGERY
X. Li, P. Koza-Taylor, M. Lawton, W. Miao, G. Warnes and S. Eustis
Keyword: Cardiovascular, Abstract #166

4:45 p.m. - 5:00 p.m.
LASER MICRODISSECTION (LMD) FOR TOXICOGENOMIC ELUCIDATION OF MECHANISMS OF RENAL TOXICITY
D. Weinstock, W. Hu, M. Taurino, M. Wojke, Z. Jayyosi, and T. Monticello
Keyword: Toxicologic Pathology, Abstract #167

Toxicologic Pathology Poster Presentations:

T-1	TCDD-INDUCED PROLIFERATION OF LUNG EPITHELIAL CELLS POST-INFLUENZA VIRUS INFECTION IS NOT DUE TO INCREASED TISSUE DAMAGE A.A. Bohn, S. Teske, and B.P. Lawrence Keyword: Toxicologic Pathology, Abstract #168
T-2	AN OVINE MODEL OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) SECONDARY TO INHALATION OF CHLORINE GAS E.J. Dick Jr., D. Martini, B. Jordan, R. Walton, M. Lucas, A. Batchinsky, and L. Cancio Keyword: Respiratory System, Abstract #169
T-3	PHYSEAL HYPERTROPHY IS A PHARMACOLOGIC BIOMARKER FOR TRANSFORMING GROWTH FACTOR-b RECEPTOR INHIBITORY ACTIVITY IN RATS K.S. Frazier, J.B. Nold, M.S. Scicchitano, R. Thomas, E. Grygielko, N. Laping, F. Gellibert, A. DeGouville, and S. Huet Keyword: Toxicologic Pathology, Abstract #170
T-4	EXPERIMENTAL TRANSMISSION OF CHRONIC WASTING DISEASE AGENT TO CATTLE BY INTRACEREBRAL ROUTE: FINAL OUTCOME OF THE STUDY A.N. Hamir, R.A. Kunkle, J.A. Richt, R.C. Cutlip, and J.M. Miller Keyword: Nervous System, Abstract #171
T-5	USE OF CALBINDIN D-28 AND MICROTUBULE ASSOCIATED PROTEIN-2 IMMUNOHISTOCHEMISTRY TO CHARACTERISE NEUROTOXICITY AS PART OF A REGULATORY TOXICITY STUDY R. Haworth, N. McCormick, S. Selway, and A.M. Pilling Keyword: Nervous System, Abstract #172
T-6	DIFFERENTIAL EXPRESSION OF COX-1 AND COX-2 IN THE GASTROINTESTINAL TRACT OF THE RAT R. Haworth, K. Oakley, N. McCormick and A. Pilling Keyword: Alimentary System, Abstract #173
T-7	HISTOPATHOLOGICAL EFFECTS OF CIPROFLOXACIN ON RAT FETAL HEART DEVELOPMENT A. Khaki, N. Nilforoshan, A.A. Khaki, and Y. Azarmi Keyword: Toxicologic Pathology, Abstract #174
T-8	GENETIC ALTERATIONS IN BRAIN TUMORS FROM 1,3 BUTADIENE-TREATED B6C3F1 MICE Y. Kim, H.L. Hong, Y. Lachat, N. Clayton, M.E. Hegi, T. Devereux, R. Melnick, and R.C. Sills Keyword: Nervous System, Abstract #175
T-9	ENHANCED IMAGE ANALYSIS OF A TRANSPARENT FISH MODEL M. Law, K. Hobbie, R. Hardman, S. Kullma, and D. Hinton Keyword: Toxicologic Pathology, Abstract #176
T-10*	BRONCHOSCOPIC ADMINISTRATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR INDUCES A DOSE-DEPENDENT MONOCYTE RECRUITMENT IN NEONATAL LAMBS D.K. Meyerholz, B. Grubor, T. Lazic, J.M. Snyder, P.B. McCray Jr., and M.R. Ackermann Keyword: Toxicologic Pathology, Abstract #177
T-11	LESIONS OF SKELETAL MUSCLE INDUCED BY CLOFIBRATE IN RATS M. Okada, T. Tsuchiya, Y. Inoue, M. Ube, F. Sano, J. Sugimoto, and S. Takagi Keyword: Nervous System, Abstract #178
T-12	EFFECTS OF NONYLPHENOL ON THE EXPERIMENTAL HEPATOCARCINOGENESIS IN MALE RATS K.D. Park, B.S. Han, C.K. Kim, K.T. Nam, W.S. Cho, M.N. Choi, K.H. Yang and D.D. Jang Keyword: Toxicologic Pathology, Abstract #179
T-13	ENHANCED NEUTROPHIL TRANSMIGRATION IS THE POSSIBLE MECHANISM BEHIND INCREASED SUSCEPTIBILITY OF FEMALES TO ALCOHOLIC STEATOHEPATITIS A. Banerjee, U.M. Apte, and S.K. Ramaiah Keyword: Toxicologic Pathology, Abstract #180
T-14	EFFECT OF COMBINED ABAMECTIN AND BIFENTHRIN ON MACRO AND MICROMINERAL TISSUE CONCENTRATIONS OF BLACK ROCK PIGEONS (COLUMBA LIVIA) Zia-ur-Rahman, M.A. Sandhu, T. Siddique and A. Yousaf Keyword: Avian, Abstract #181
T-15	EFFECT OF COMBINED ABAMECTIN AND BIFENTHRIN ADMINISTRATION ON HEMATOLOGICAL AND PLASMA BIOCHEMICAL PROFILE OF BLACK ROCK PIGEONS (COLUMBA LIVIA) A. Yousaf, Zia-ur-Rahman, T. Siddique and M. A. Sandhu Keyword: Hematology, Abstract #182
T-16	CHARACTERIZATION OF RAT ENDOMETRIAL STROMAL SARCOMA-DERIVED TUMOR LINES J. Yamate, Y. Yokoyama, M. Kuwamura, T. Kotani, and S. Sakuma Keyword: Reproductive System, Abstract #183
T-17	GENETIC ALTERATIONS IN RAS, P53, AND BETA-CATENIN GENES IN HEMANGIOSARCOMAS OF B6C3F1 MICE FOLLOWING EXPOSURE TO ENVIRONMENTAL CHEMICALS FOR TWO YEARS T. Ton, H. Hong, T. Devereux, J. Dunnick, and R. Sills Keyword: Toxicologic Pathology, Abstract #184
T-18	THE OVARY OF THE RAT AND YOLK SAC CARCINOMA G.Z. Kaminska-McNamara and P. Losco Keyword: Reproductive System, Abstract #185

*Competitor for ACVP Young Investigator Award
**Competitor for 2004 Christopher T. Starost Memorial Oncology Scholarship

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