Major Duties:

• Extract implicit and novel information from complex and large databases to characterize genes involved in the physiological and/or pathological state following drug therapy. This is done by integrating and synthesizing the information from databases with bioinformatics tools as well as with statistical, partitioning and visualization techniques. The goal is to find a profile or signature for a treatment or for a side effect, to provide hypotheses for mechanistic pathways, to propose potential biomarkers linked to mechanisms, or to predict potential new therapeutic indications.
• Exploit to their best the interactions between gene expression analysis ? localization/LCM techniques and histopathology to support the concept of integrated molecular pathology
• Possibly supports exploratory studies by histopathology assessment.
• Interact with NIBR colleagues (TS and beyond) e.g., project team representatives, study directors, pathologists?
• Prepare reports and contributions to phase-transition and registration documents.
• Present results to project team and management.
• Guide efforts to integrate information from multiple functions (Pathology, PK/PD, modeling, functional validation, and bioassay development).
• Mentor and train new hires.
• Maintain a strong awareness of current methodologies through participation at scientific meetings and reviewing current literature in discipline and related areas.
• Continue scientific career development as demonstrated by internal and external lecture presentations and publication in reference journals.
• Maintain working knowledge of relevant Novartis policies and procedures.
• Support NIBR and line function goals and objectives.Education: MD, DVM or PhD in life sciences.
  

Extensive operational knowledge of histology and basic pathology.
 
Basic knowledge of molecular biology techniques and biomedical statistics
 
Experience: Significant scientific experience working in histology, pathology or molecular pathology
 
Technical Ability: Experience interpretation of gene expression profiles and integration in the context of a specific apthology/disease
 
Excellence in data summarization
 
Presentation: Excellent oral and written communication skills. Able to present and defend data and to influence the decision process regarding study design.
 
To apply for this position, please copy and paste the following link into your browser address bar:
http://novartis.contacthr.com/13929499

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